|Description||Rabbit IgG polyclonal antibody for Complement factor D(CFD) detection. Tested with WB in Mouse.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Complement factor D, 18.104.22.168, 28 kDa adipocyte protein, Adipsin, C3 convertase activator, Properdin factor D, Cfd, Adn, Df|
|Calculated MW||28057 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Mouse|
|Protein Name||Complement factor D|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||E. coli-derived mouse Factor D recombinant protein (Position: Q30-K235). Mouse Factor D shares 66.5% and 87.4% amino acid (aa) sequence identity with human and rat Factor D, respectively.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins.|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.|
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Provided below are standard protocols that you may find useful for product applications.
Factor D is aÂ proteinÂ which in humans is encoded by theÂ CFDÂ gene. The protein encoded by this gene is a member of theÂ trypsinÂ family of peptidases. The encoded protein is a component of theÂ alternative complement pathwayÂ best known for its role in humoral suppression of infectious agents. It is also a serine protease that is secreted byÂ adipocytesÂ into the bloodstream. And it stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.
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