|Application ||WB, E|
|Description||Rabbit IgG polyclonal antibody for C-X-C motif chemokine 2(CXCL2) detection. Tested with WB, ELISA in Human.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||C-X-C motif chemokine 2, Growth-regulated protein beta, Gro-beta, Macrophage inflammatory protein 2-alpha, MIP2-alpha, GRO-beta(5-73), GRO-beta-T, Hematopoietic synergistic factor, HSF, SB-251353, CXCL2, GRO2, GROB, MIP2A, SCYB2|
|Calculated MW||11389 MW KDa|
|Application Details||ELISA , 0.1-0.5 µg/ml, Human, -|
Western blot, 0.1-0.5 µg/ml, Human
|Protein Name||C-X-C motif chemokine 2|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||E. coli-derived human CXCL2 recombinant protein (Position: T39-N107). Human CXCL2 shares 66.7% and 62.3% amino acid (aa) sequence identity with mouse and rat CXCL2, respectively.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins.|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Synonyms||GRO2, GROB, MIP2A, SCYB2|
|Function||Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.|
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Chemokine (C-X-C motif) ligand 2Â (CXCL2) is a smallÂ cytokineÂ belonging to the CXCÂ chemokineÂ family that is also calledÂ macrophage inflammatory protein 2-alphaÂ (MIP2-alpha),Â Growth-regulated protein betaÂ (Gro-beta) andÂ Gro oncogene-2(Gro-2). CXCL2 is 90% identical inÂ amino acidÂ sequence as a related chemokine,Â CXCL1. This chemokine is secreted by monocytesÂ andÂ macrophagesÂ and isÂ chemotacticÂ forÂ polymorphonuclear leukocytesÂ andÂ hematopoietic stem cells. The gene for CXCL2 is located on humanÂ chromosome 4Â in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surfaceÂ chemokine receptorÂ calledÂ CXCR2.
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