|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Description||Rabbit IgG polyclonal antibody for Alpha-1-acid glycoprotein 1(ORM1) detection. Tested with WB, IHC-P, ELISA in Human;Mouse;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Alpha-1-acid glycoprotein 1, AGP 1, Orosomucoid-1, OMD 1, ORM1, AGP1|
|Calculated MW||23512 MW KDa|
|Application Details||Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat|
ELISA , 0.1-0.5 µg/ml, Human, -
Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
|Tissue Specificity||Expressed by the liver and secreted in plasma.|
|Protein Name||Alpha-1-acid glycoprotein 1|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||E. coli-derived human ORM1 recombinant protein (Position: Q19-S201). Human ORM1 shares 47.5% and 48.1% amino acid (aa) sequence identity with mouse and rat ORM1, respectively.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. The structural gene for orosomucoid (ORM1) is assigned to the end of the long arm of chromosome 9 by demonstration of linkage to ABO and AK1. This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.
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