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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-SLC2A5 Picoband Antibody   

Anti-SLC2A5 Picoband Antibody

     
  • WB - Anti-SLC2A5 Picoband Antibody ABO12645
    Western blot analysis of SLC2A5 expression in rat brain extract (lane 1), and K562 whole cell lysates (lane 2). SLC2A5 at 55KD was detected using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody (Catalog # ABO12645) at 0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method .
  • IHC - Anti-SLC2A5 Picoband Antibody ABO12645
    SLC2A5 was detected in paraffin-embedded sections of rat intestine cancer tissues using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody (Catalog # ABO12645) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
  • IHC - Anti-SLC2A5 Picoband Antibody ABO12645
    SLC2A5 was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti-SLC2A5 Antigen Affinity purified polyclonal antibody (Catalog # ABO12645) at 1 ??g/mL. The immunohistochemical section was developed using SABC method .
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P22732
Host Rabbit
Reactivity Human, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 5(SLC2A5) detection. Tested with WB, IHC-P in Human;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 6518
Other Names Solute carrier family 2, facilitated glucose transporter member 5, Fructose transporter, Glucose transporter type 5, small intestine, GLUT-5, SLC2A5, GLUT5
Calculated MW 54974 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, By Heat

Western blot, 0.1-0.5 µg/ml, Human, Rat
Subcellular Localization Apical cell membrane ; Multi- pass membrane protein . Membrane; Multi-pass membrane protein. Localized on the apical membrane of the small intestine and the proximal tubule of the kidney. .
Tissue Specificity Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.
Protein Name Solute carrier family 2, facilitated glucose transporter member 5
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human SLC2A5 (223-259aa QKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKA), different from the related mouse and rat sequences by nine amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name SLC2A5
Synonyms GLUT5
Function Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
Cellular Location Apical cell membrane {ECO:0000250|UniProtKB:Q9WV38}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WV38}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WV38}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P43427}. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A {ECO:0000250|UniProtKB:Q9WV38}
Tissue Location Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue
Research Areas
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Background

SLC2A5, also known as GLUT5 (Glucose transporter 5), is a fructose transporter expressed on the apical border of enterocytes in the small intestine. The GLUT5 gene is located on chromosome 1. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue, and brain. Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.

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$ 280.00
Cat# ABO12645
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