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Caspase-11 Antibody

Rabbit Polyclonal Antibody

  • WB - Caspase-11 Antibody ABV10014-30
    Western blot analysis of Caspase 11 with 3T3 cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P70343
Other Accession NM_007609
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 42742 Da
Additional Information
Gene ID 12363
Application & Usage Western blotting (0.5-4 µg/ml). The antibody detects procaspase-11 (45 kDa), a partially cleaved fragment (30 kDa) and fully cleaved fragment (20 kDa). A 58 kDa unknown identity band was also detected in 3T3 cells.
Other Names CASP-11, ICEB, ICH-3
Target/Specificity Caspase-11
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) protein A purified rabbit anti-caspase-11 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCaspase-11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp4
Synonyms Casp11, Caspl, Ich3
Function Proinflammatory caspase (PubMed:8702803, PubMed:9038361, PubMed:25119034). Essential effector of NLRP3 inflammasome- dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria (PubMed:22002608). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:22002608, PubMed:26320999, PubMed:26375003). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of the infection (>3 days post infection), LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in the pyroptosis of the infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752). Involved in LPS- induced IL6 secretion; this activity may not require caspase enzymatic activity (By similarity). Involved in cell death induced by endoplasmic reticulum stress (By similarity). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:8702803, PubMed:9038361). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49662}. Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49662}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49662}; Cytoplasmic side {ECO:0000250|UniProtKB:P49662}. Mitochondrion {ECO:0000250|UniProtKB:P49662}. Inflammasome. Secreted {ECO:0000250|UniProtKB:P49662}. Note=Predominantly localizes to the endoplasmic reticulum (ER). Association with the ER membrane requires TMEM214. Released in the extracellular milieu by keratinocytes following UVB irradiation {ECO:0000250|UniProtKB:P49662}
Tissue Location Widely expressed, including in thymus, lung and spleen (at protein level). Very low levels, if any, in the brain.
Research Areas
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Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-11 is also synthesized as inactive pro-enzyme that are processed in cells undergoing apoptosis or inflammation. The processed form of caspase-11 consists of large and small subunits which associate to form an active enzyme.

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$ 265.00
Cat# ABV10014-30
Availability: 5-7days
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