|Reactivity||Human, Mouse, Rat|
|Calculated MW||38091 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). Per researchers feedback, it also works well in Immunohistochemistry (10-20 µg/ml, frozen and paraffin sections). However, the optimal conditions should be determined individually.|
|Other Names||connective tissue growth factor, CCN2 , CCN-2, CCN 2, Hypertrophic chondrocyte-specific protein 24|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-CTGF polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||CTGF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CCN2, HCS24, IGFBP8|
|Function||Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
|Tissue Location||Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested|
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Provided below are standard protocols that you may find useful for product applications.
CTGF (connective tissue growth factor) is a cysteine-rich, secreted peptide. It is a new member of the peptide family that includes serum-induced immediate early gene products, a v-src-induced peptide, and a putative proto-oncogene. Among the many functions of the CTGF gene family are embryogenesis, wound healing, and regulation of extracellular matrix production.
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