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Nucleostemin/GLN3 Antibody (CT)

Rabbit Polyclonal Antibody

  • WB - Nucleostemin/GLN3 Antibody (CT) ABV11324-100
    Western blot analysis of GNL3 Antibody in HL60 cell line lysates (35 μg/lane). GNL3 (arrow) was detected using the purified pAb.
  • IHC - Nucleostemin/GLN3 Antibody (CT) ABV11324-100
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with GNL3 antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BVP2
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 61993 Da
Additional Information
Gene ID 26354
Positive Control Western blot: HL60 cell line lysate, IHC: human hepatocarcinoma tissue.
Application & Usage WB: 1:1000, IHC: 1:10 – 1:50.
Other Names GNL3; E2IG3; NS; Guanine nucleotide-binding protein-like 3; E2-induced gene 3 protein; Novel nucleolar protein 47; Nucleolar GTP-binding protein 3; Nucleostemin
Target/Specificity Nuclerostemin
Antibody Form Liquid
Appearance Colorless liquid
Formulation This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsNucleostemin/GLN3 Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNL3
Synonyms E2IG3, NS
Function May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus, nucleolus Note=Shuttles between the nucleus and nucleolus {ECO:0000250|UniProtKB:Q811S9}
Tissue Location Increased levels in lung tissue in cancer patients.
Research Areas
Citations (0)

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Nucleostemin, also designated Nucleolar GTP-binding protein 3, is a member of the MMR1/HSR1 GTP-binding protein family. It is expressed in the nucleoli of adult CNS stem cells, primitive bone marrow cells, and embryonic stem cells and in several cancer cell lines. Nucleostemin is often used as a stem cell marker. Overexpression or depletion of the protein can reduce cell proliferation in CNS stem cells. Nucleostemin shuttles between the nucleus and the nucleolus and may be important in maintaining the proliferative capacity of stem cells. Nucleostemin is important in the growth regulation of liver cancer, gastric cancer and several other cancer types. The gene encoding Nucleostemin is localized to chromosome 3p21.1.

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$ 245.00
Cat# ABV11324-100
Availability: 5-7days
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