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Phospho Alpha-synuclein (Tyr125) Antibody

     
  • WB - Phospho Alpha-synuclein (Tyr125) Antibody ABV11950-100
    WB analysis of Alphasynuclein (pY125) expression in HeLa (A); mouse brain (B); rat brain (C) whole cell lysates
  • IHC - Phospho Alpha-synuclein (Tyr125) Antibody ABV11950-100
    Immunohistochemical analysis of Alpha-synuclein (pY125) staining in human brain formalin fixed paraffin embedded tissue section.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IH
Primary Accession P37840
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype Rabbit IgG
Calculated MW 14460 Da
Additional Information
Gene ID 6622
Positive Control WB; HeLa, mouse brain, rat brain lysate, IHC; human brain tissue
Application & Usage WB; 1:500 – 1:2000, IHC; 1:50 – 1:200
Other Names NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Target/Specificity SNCA
Antibody Form Liquid
Appearance Colorless liquid
Handling The antibody solution should be gently mixed before use
Reconstitution & Storage -20°C
Background Descriptions
PrecautionsPhospho Alpha-synuclein (Tyr125) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNCA
Synonyms NACP, PARK1
Function Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein- alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).
Cellular Location Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted. Note=Membrane-bound in dopaminergic neurons.
Tissue Location Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain
Research Areas
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$ 325.00
Cat# ABV11950-100
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