|Isotype||Mouse IgG1, κ|
|Calculated MW||68678 Da|
|Application & Usage||ELISA Capture: 1-10 µg/ml, ELISA Detection: 0.05-0.2 µg/ml|
|Other Names||Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP, AFP, Alpha-fetoprotein|
|Reconstitution & Storage||-20 °C|
|Precautions||Anti-AFP Antibody (2E1C10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.|
|Tissue Location||Plasma. Synthesized by the fetal liver and yolk sac|
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Provided below are standard protocols that you may find useful for product applications.
AFP (Alpha-Feto Protein) is a glycoprotein with molecular weight of approximately 70 kDa. It is a major protein in developing fetus and decreases to lower level after birth. In healthy adults, less than 20 ng/ml of AFP is found in the serum. Serum AFP elevates when hepatocellular carcinoma or testicular germ cell tumors occurs. Therefore, it is a useful marker in diagnosing hepatocellular carcinoma and germ cell tumors. In addition, for pregnant women, the AFP concentration is 10-150 ng/ml in the blood. High levels of AFP can indicate a neural tube defect of the fetus, such us spina bifida. AFP Antibody is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from mouse immunized with AFP protein purified from human hepatocellular carcinoma
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