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Functional IL-1R2 (mouse) Antibody, mAb (recombinant)

  • FC - Functional IL-1R2 (mouse) Antibody, mAb (recombinant) ADP0040
    Detection of endogenous mouse IL-1R2 with IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) . Method: In vitro-cultivated BMN (mouse Neutrophils) (stimulated 24h with hydrocortisone) were stained with IL-1R2 (mouse), mAb (rec.) (Praxy-1-1) (thick green line) or an isotype control (thin black line) at 5ug/ml each, revealed with a secondary anti-mouse antibody (FITC) and then analyzed by flow cytometry.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P27931
Reactivity Mouse
Host Purified From HEK 293 Cell culture Supernatant.
Clonality Monoclonal
Isotype Mouse IgG2bλ
Gene Source Mouse
Endotoxin <0.01EU/ µg purified protein (LAL-test; Lonza).
Application Note ,E,Detection,FC(1:100),
Clone Names Praxy-1-1
Calculated MW 45645 Da
Description IL-1R2 (mouse) monoclonal antibody (recombinant) (Praxy-1-1) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the mouse IgG2b Fc domain.
Additional Information
Gene ID 16178
Other Names CD121 Antigen-like Family Member B; IL-1 Type II Receptor; Interleukin-1 Receptor β Interleukin-1 Receptor Type II; CD121b
Target/Specificity Recognizes mouse IL-1R2.
Format Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Reconstitution & Storage Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C.
PrecautionsFunctional IL-1R2 (mouse) Antibody, mAb (recombinant) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Il1r2
Synonyms Il-1r2, Il1rb
Function Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein. Cell membrane. Secreted
Tissue Location Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1.
Research Areas
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The inflammatory actions of IL-1α and -β- depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.

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$ 300.00
Cat# ADP0040
Availability: 3-5 days
Bulk Size
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