|Application ||WB, IHC, E|
|Other Accession||NP_000662, 128, 11532 (mouse)|
|Reactivity||Human, Mouse, Rat|
|Predicted||Pig, Dog, Cow|
|Calculated MW||39724 Da|
|Other Names||Alcohol dehydrogenase class-3, 184.108.40.206, Alcohol dehydrogenase 5, Alcohol dehydrogenase class chi chain, Alcohol dehydrogenase class-III, Glutathione-dependent formaldehyde dehydrogenase, FALDH, FDH, GSH-FDH, 1.1.1.-, S-(hydroxymethyl)glutathione dehydrogenase, 220.127.116.114, ADH5 (HGNC:253), ADHX, FDH|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ADH5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene.
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis. Wei W, et al. Sci Transl Med, 2010 Feb 17. PMID 20371487.
GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol. Choudhry S, et al. Pharmacogenet Genomics, 2010 Jun. PMID 20335826.
Associations between ADH gene variants and alcohol phenotypes in Dutch adults. van Beek JH, et al. Twin Res Hum Genet, 2010 Feb. PMID 20158305.
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