|Application ||WB, E|
|Other Accession||NP_006399, 10551, 23795 (mouse)|
|Calculated MW||19979 Da|
|Other Names||Anterior gradient protein 2 homolog, AG-2, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog, AGR2, AG2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-AGR2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).|
|Cellular Location||Secreted. Endoplasmic reticulum|
|Tissue Location||Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia. Chen R, et al. Mol Cancer, 2010 Jun 15. PMID 20550709.
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Lipkin SM, et al. Cancer Prev Res (Phila), 2010 May. PMID 20403997.
ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer. Zhang Y, et al. Cancer Res, 2010 Jan 1. PMID 20048076.
The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients. Barraclough DL, et al. Am J Pathol, 2009 Nov. PMID 19834055.
Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma. Riener MO, et al. Histol Histopathol, 2009 Sep. PMID 19609859.
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