|Application ||WB, E|
|Other Accession||NP_065712, 57379|
|Calculated MW||23954 Da|
|Other Names||Single-stranded DNA cytosine deaminase, 18.104.22.168, Activation-induced cytidine deaminase, Cytidine aminohydrolase, AICDA, AID|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-AID Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).|
|Cellular Location||Nucleus. Cytoplasm Note=Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.|
|Tissue Location||Strongly expressed in lymph nodes and tonsils.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA. Maeda K, et al. J Biol Chem, 2010 Jul 30. PMID 20507984.
TP53 mutations coincide with the ectopic expression of activation-induced cytidine deaminase in the fibroblast-like synoviocytes derived from a fraction of patients with rheumatoid arthritis. Igarashi H, et al. Clin Exp Immunol, 2010 Jul 1. PMID 20491788.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese. Hishida A, et al. Gastric Cancer, 2010 Mar. PMID 20373075.
Determinants of sequence-specificity within human AID and APOBEC3G. Carpenter MA, et al. DNA Repair (Amst), 2010 May 4. PMID 20338830.
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