|Application ||WB, E|
|Other Accession||NP_064695, 57016|
|Calculated MW||36020 Da|
|Other Names||Aldo-keto reductase family 1 member B10, 1.1.1.-, ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase, AKR1B10, AKR1B11|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-AKR1B10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans- 2,4-hexadienal and their glutathione-conjugates carbonyls (GS- carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).|
|Cellular Location||Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway|
|Tissue Location||Found in many tissues. Highly expressed in small intestine, colon and adrenal gland|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
[Downregulation of AKR1B10 gene expression in colorectal cancer] Kropotova ES, et al. Mol Biol (Mosk), 2010 Mar-Apr. PMID 20586184.
Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours. Heringlake S, et al. J Hepatol, 2010 Feb. PMID 20036025.
Novel role for aldose reductase in mediating acute inflammatory responses in the lung. Ravindranath TM, et al. J Immunol, 2009 Dec 15. PMID 20007578.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
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