|Application ||WB, IHC, E|
|Other Accession||NP_647477, 273, 218038 (mouse)|
|Calculated MW||76257 Da|
|Other Names||Amphiphysin, AMPH, AMPH1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Amphiphysin / AMPH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton|
|Tissue Location||Neurons, certain endocrine cell types and spermatocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
Applying chemometrics approaches to model and predict the binding affinities between the human amphiphysin SH3 domain and its peptide ligands. Liu L, et al. Protein Pept Lett, 2010 Feb. PMID 20214647.
Toward quantitative characterization of the binding profile between the human amphiphysin-1 SH3 domain and its peptide ligands. He P, et al. Amino Acids, 2010 Apr. PMID 19669081.
Modeling and prediction of binding affinities between the human amphiphysin SH3 domain and its peptide ligands using genetic algorithm-Gaussian processes. Zhou P, et al. Biopolymers, 2008. PMID 18814309.
Characterization of domain-peptide interaction interface: a case study on the amphiphysin-1 SH3 domain. Hou T, et al. J Mol Biol, 2008 Feb 29. PMID 18206907.
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