|Application ||WB, E|
|Other Accession||NP_848605, 255239|
|Calculated MW||84632 Da|
|Other Names||Ankyrin repeat and protein kinase domain-containing protein 1, 22.214.171.124, Protein kinase PKK2, Sugen kinase 288, SgK288, X-kinase, ANKK1, PKK2, SGK288|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ANKK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Highly expressed in brain and weakly expressed in placenta and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP.
Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts novelty seeking and harm avoidance. Montag C, et al. Neuropsychopharmacology, 2010 Aug. PMID 20410875.
[DRD2/ANKK1 Taq IA polymorphism and early infant temperament] Ma J, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2010 Feb. PMID 20199723.
CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. Sj枚holm LK, et al. J Circadian Rhythms, 2010 Jan 21. PMID 20180986.
A genetic schizophrenia-susceptibility region located between the ANKK1 and DRD2 genes. Dubertret C, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2010 Apr 16. PMID 20138949.
Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans. David SP, et al. Nicotine Tob Res, 2010 Mar. PMID 20133381.
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