|Application ||WB, E|
|Other Accession||NP_000375, 338|
|Calculated MW||515605 Da|
|Other Names||Apolipoprotein B-100, Apo B-100, Apolipoprotein B-48, Apo B-48, APOB|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-APOB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.|
|Cellular Location||Cytoplasm. Secreted|
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Provided below are standard protocols that you may find useful for product applications.
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
ApoB genetic variants modify the response to fenofibrate: a GOLDN study. Wojczynski MK, et al. J Lipid Res, 2010 Aug 19. PMID 20724655.
Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients. Hu M, et al. Pharmacogenet Genomics, 2010 Oct. PMID 20679960.
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Johansen CT, et al. Nat Genet, 2010 Aug. PMID 20657596.
[Distribution characteristics of ApoB3'VNTR and hyperlipemia correlation factors in civil aircrew] Zhu F, et al. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2010 Mar. PMID 20635694.
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