|Application ||WB, E|
|Other Accession||NP_001635, 339, 11810 (mouse)|
|Calculated MW||28192 Da|
|Other Names||C->U-editing enzyme APOBEC-1, 3.5.4.-, Apolipoprotein B mRNA-editing enzyme 1, HEPR, APOBEC1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-APOBEC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.|
|Tissue Location||Expressed exclusively in the small intestine.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Hypermutation induced by APOBEC-1 overexpression can be eliminated. Chen Z, et al. RNA, 2010 May. PMID 20348446.
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. Mosbruger TL, et al. J Infect Dis, 2010 May 1. PMID 20331378.
Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans. Weissglas-Volkov D, et al. Arterioscler Thromb Vasc Biol, 2010 Feb. PMID 19965785.
The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells. Galloway CA, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19932086.
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