|Application ||IHC, E|
|Other Accession||NP_061974, 55937|
|Calculated MW||21253 Da|
|Other Names||Apolipoprotein M, Apo-M, ApoM, Protein G3a, APOM, G3A, NG20|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-APOM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|
|Cellular Location||Secreted Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL)|
|Tissue Location||Plasma protein. Expressed in liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Rua帽o G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615.
Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia. Ahnstr枚m J, et al. Clin Biochem, 2010 Apr. PMID 20080084.
WITHDRAWN: Association of apolipoprotein M gene polymorphisms with cerebral infarction and lipid levels in a Chinese Han population. Han X, et al. Neuroscience, 2009 Nov 20. PMID 19932739.
Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms. Ahnstr枚m J, et al. Clin Biochem, 2010 Mar. PMID 19932694.
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