|Application ||WB, E|
|Other Accession||NP_000036, 383|
|Calculated MW||34735 Da|
|Other Names||Arginase-1, 188.8.131.52, Liver-type arginase, Type I arginase, ARG1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Arginase, type 1 / ARG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.|
|Cellular Location||Cytoplasm. Cytoplasmic granule. Note=Localized in azurophil granules of neutrophils (PubMed:15546957)|
|Tissue Location||Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also detected in macrophages mycobacterial granulomas (PubMed:23749634). Expressed in group2 innate lymphoid cells (ILC2s) during lung disease (PubMed:27043409).|
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Provided below are standard protocols that you may find useful for product applications.
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.
Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. Yan BC, et al. Am J Surg Pathol, 2010 Aug. PMID 20661013.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.
Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. Zabaleta J, et al. Int J Cancer, 2010 Apr 14. PMID 20473875.
Human eosinophil granulocytes do not express the enzyme arginase. Luckner-Minden C, et al. J Leukoc Biol, 2010 Jun. PMID 20200399.
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