|Application ||WB, E|
|Other Accession||NP_112503, 1588|
|Calculated MW||57883 Da|
|Other Names||Aromatase, 22.214.171.124, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Aromatase / CYP19A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARO1, CYAR, CYP19|
|Function||Catalyzes the formation of aromatic C18 estrogens from C19 androgens.|
|Cellular Location||Membrane; Peripheral membrane protein.|
|Tissue Location||Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
Association of CYP19 and ESR1 Pleiotropic Genes With Human Longevity. Corbo RM, et al. J Gerontol A Biol Sci Med Sci, 2010 Sep 5. PMID 20819792.
Epistasis between CYP19A1 and ESR1 polymorphisms is associated with premature ovarian failure. Kim S, et al. Fertil Steril, 2010 Aug 24. PMID 20797716.
Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs. Kohno T, et al. Carcinogenesis, 2010 Aug 5. PMID 20688833.
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Canzian F, et al. Hum Mol Genet, 2010 Oct 1. PMID 20634197.
Genetic susceptibility to urinary incontinence: implication of polymorphisms of androgen and oestrogen pathways. Cornu JN, et al. World J Urol, 2010 Jul 14. PMID 20628746.
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