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Goat Anti-BHMT Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-BHMT Antibody AF1150a
    AF1150a (0.03 µg/ml) staining of Rat Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-BHMT Antibody AF1150a
    HEK293 overexpressing BHMT RC203148) and probed with AF1150a (mock transfection in first lane), tested by Origene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q93088
Other Accession NP_001704, 635, 12116 (mouse), 81508 (rat)
Reactivity Human, Mouse, Rat
Predicted Dog
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Additional Information
Other Names Betaine--homocysteine S-methyltransferase 1,, BHMT
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-BHMT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
Cellular Location Cytoplasm.
Tissue Location Found exclusively in liver and kidney. EMBL; U50929; AAC50668.1; -; mRNA EMBL; AF118378; AAD22043.1; -; Genomic_DNA EMBL; AF118371; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118372; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118373; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118374; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118375; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118376; AAD22043.1; JOINED; Genomic_DNA EMBL; AF118377; AAD22043.1; JOINED; Genomic_DNA EMBL; BC012616; AAH12616.1; -; mRNA CCDS; CCDS4046.1; - RefSeq; NP_001704.2; NM_001713.2 UniGene; Hs.80756; - PDB; 1LT7; X-ray; 2.15 A; A/B=1-406 PDB; 1LT8; X-ray; 2.05 A; A/B=1-406 PDB; 4M3P; X-ray; 1.90 A; A/B/C/D=1-406 PDBsum; 1LT7; - PDBsum; 1LT8; - PDBsum; 4M3P; - ProteinModelPortal; Q93088; - SMR; Q93088; - BioGrid; 107104; 11 IntAct; Q93088; 5 MINT; Q93088; - STRING; 9606.ENSP00000274353; - BindingDB; Q93088; - ChEMBL; CHEMBL4328; - DrugBank; DB04272; Citric Acid DrugBank; DB00134; L-Methionine DrugBank; DB02337; S-(D-Carboxybutyl)-L-Homocysteine iPTMnet; Q93088; - PhosphoSitePlus; Q93088; - BioMuta; BHMT; - DMDM; 145559446; - EPD; Q93088; - PaxDb; Q93088; - PeptideAtlas; Q93088; - PRIDE; Q93088; - ProteomicsDB; 75719; - Ensembl; ENST00000274353; ENSP00000274353; ENSG00000145692 GeneID; 635; - KEGG; hsa:635; - CTD; 635; - DisGeNET; 635; - EuPathDB; HostDB:ENSG00000145692.14; - GeneCards; BHMT; - HGNC; HGNC:1047; BHMT HPA; HPA038285; - HPA; HPA058310; - MIM; 602888; gene neXtProt; NX_Q93088; - OpenTargets; ENSG00000145692; - PharmGKB; PA25350; - eggNOG; KOG1579; Eukaryota eggNOG; COG0646; LUCA GeneTree; ENSGT00390000003122; - HOGENOM; HOG000231636; - HOVERGEN; HBG080367; - InParanoid; Q93088; - KO; K00544; - OMA; PYCPSMS; - OrthoDB; 731388at2759; - PhylomeDB; Q93088; - TreeFam; TF329202; - BioCyc; MetaCyc:HS07273-MONOMER; - BRENDA;; 2681 Reactome; R-HSA-1614635; Sulfur amino acid metabolism Reactome; R-HSA-6798163; Choline catabolism SABIO-RK; Q93088; - SIGNOR; Q93088; - UniPathway; UPA00051; UER00083 UniPathway; UPA00291; UER00432 ChiTaRS; BHMT; human EvolutionaryTrace; Q93088; - GenomeRNAi; 635; - PRO; PR:Q93088; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000145692; Expressed in 93 organ(s), highest expression level in kidney epithelium ExpressionAtlas; Q93088; baseline and differential Genevisible; Q93088; HS GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB GO; GO:0047150; F:betaine-homocysteine S-methyltransferase activity; IDA:BHF-UCL GO; GO:0008270; F:zinc ion binding; IDA:BHF-UCL GO; GO:0006579; P:amino-acid betaine catabolic process; IEA:UniProtKB-UniPathway GO; GO:0006577; P:amino-acid betaine metabolic process; IDA:BHF-UCL GO; GO:0042426; P:choline catabolic process; TAS:Reactome GO; GO:0071267; P:L-methionine salvage; IDA:BHF-UCL GO; GO:0006479; P:protein methylation; NAS:UniProtKB GO; GO:0050666; P:regulation of homocysteine metabolic process; NAS:UniProtKB GO; GO:0000096; P:sulfur amino acid metabolic process; TAS:Reactome Gene3D;; -; 1 InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT InterPro; IPR003726; HCY_dom InterPro; IPR036589; HCY_dom_sf Pfam; PF02574; S-methyl_trans; 1 PIRSF; PIRSF037505; Betaine_HMT; 1 SUPFAM; SSF82282; SSF82282; 1 PROSITE; PS50970; HCY; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Cytoplasm; Metal-binding; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Zinc CHAIN 1 406 Betaine--homocysteine S-methyltransferase 1 /FTId=PRO_0000114621 DOMAIN 11 314 Hcy-binding. {ECO:0000255|PROSITE- ProRule:PRU00333} METAL 217 217 Zinc METAL 299 299 Zinc METAL 300 300 Zinc MOD_RES 40 40 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 93 93 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 232 232 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 241 241 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 330 330 Phosphoserine {ECO:0000250|UniProtKB:O09171} MOD_RES 340 340 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} MOD_RES 377 377 N6-succinyllysine {ECO:0000250|UniProtKB:O35490} VARIANT 199 199 G -> S (in dbSNP:rs59866108) /FTId=VAR_061345 VARIANT 239 239 R -> Q (may decrease risk for coronary artery disease; dbSNP:rs3733890) /FTId=VAR_015886 HELIX 13 18 {ECO:0000244|PDB:4M3P} HELIX 29 35 {ECO:0000244|PDB:4M3P} TURN 41 43 {ECO:0000244|PDB:4M3P} HELIX 48 51 {ECO:0000244|PDB:4M3P} HELIX 53 66 {ECO:0000244|PDB:4M3P} STRAND 69 72 {ECO:0000244|PDB:4M3P} HELIX 97 111 {ECO:0000244|PDB:4M3P} TURN 112 115 {ECO:0000244|PDB:4M3P} STRAND 117 123 {ECO:0000244|PDB:4M3P} HELIX 126 129 {ECO:0000244|PDB:1LT8} HELIX 134 151 {ECO:0000244|PDB:4M3P} STRAND 154 162 {ECO:0000244|PDB:4M3P} HELIX 164 175 {ECO:0000244|PDB:4M3P} STRAND 181 185 {ECO:0000244|PDB:4M3P} HELIX 198 207 {ECO:0000244|PDB:4M3P} STRAND 211 219 {ECO:0000244|PDB:4M3P} HELIX 221 237 {ECO:0000244|PDB:4M3P} STRAND 243 247 {ECO:0000244|PDB:4M3P} HELIX 261 263 {ECO:0000244|PDB:4M3P} TURN 265 269 {ECO:0000244|PDB:4M3P} HELIX 272 274 {ECO:0000244|PDB:4M3P} HELIX 278 290 {ECO:0000244|PDB:4M3P} STRAND 293 296 {ECO:0000244|PDB:4M3P} HELIX 304 313 {ECO:0000244|PDB:4M3P} HELIX 315 318 {ECO:0000244|PDB:4M3P} HELIX 323 327 {ECO:0000244|PDB:4M3P} HELIX 330 335 {ECO:0000244|PDB:4M3P} HELIX 341 344 {ECO:0000244|PDB:4M3P} HELIX 349 354 {ECO:0000244|PDB:4M3P} HELIX 377 400 {ECO:0000244|PDB:4M3P} SEQUENCE 406 AA; 44998 MW; 557855B8CEDD0D54 CRC64; MPPVGGKKAK KGILERLNAG EIVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH REFLRAGSNV MQTFTFYASE DKLENRGNYV LEKISGQEVN EAACDIARQV ADEGDALVAG GVSQTPSYLS CKSETEVKKV FLQQLEVFMK KNVDFLIAEY FEHVEEAVWA VETLIASGKP VAATMCIGPE GDLHGVPPGE CAVRLVKAGA SIIGVNCHFD PTISLKTVKL MKEGLEAARL KAHLMSQPLA YHTPDCNKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWVRARARKE YWENLRIASG RPYNPSMSKP DGWGVTKGTA ELMQQKEATT EQQLKELFEK QKFKSQ
Research Areas
Citations (0)

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This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.


Maternal folate-related gene environment interactions and congenital heart defects. Hobbs CA, et al. Obstet Gynecol, 2010 Aug. PMID 20664391.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Giusti B, et al. Thromb Haemost, 2010 Aug 2. PMID 20458436.
A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.

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$ 368.00
Cat# AF1150a
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