|Application ||WB, E|
|Other Accession||NP_000738, 1140|
|Predicted||Mouse, Rat, Cow|
|Calculated MW||56698 Da|
|Other Names||Acetylcholine receptor subunit beta, CHRNB1, ACHRB, CHRNB|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CHRNB1 / ACHRB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Saccone NL, et al. Genes Brain Behav, 2010 Jun 22. PMID 20584212.
Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population. Philibert RA, et al. Nicotine Tob Res, 2009 Mar. PMID 19307444.
Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions. Lee WY, et al. J Neurosci, 2009 Mar 11. PMID 19279256.
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Saccone NL, et al. Am J Med Genet B Neuropsychiatr Genet, 2009 Jun 5. PMID 19259974.
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Gratac貌s M, et al. Am J Med Genet B Neuropsychiatr Genet, 2009 Sep 5. PMID 19086053.
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