|Application ||WB, E|
|Other Accession||NP_055428, 23197, 76577 (mouse)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||52623 Da|
|Other Names||FAS-associated factor 2, Protein ETEA, UBX domain-containing protein 3B, UBX domain-containing protein 8, FAF2, ETEA, KIAA0887, UBXD8, UBXN3B|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ETEA / UBXD8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ETEA, KIAA0887, UBXD8, UBXN3B|
|Function||Plays an important role in endoplasmic reticulum- associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).|
|Cellular Location||Cytoplasm. Lipid droplet. Endoplasmic reticulum|
|Tissue Location||Broadly expressed, with highest levels in brain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Phan VT, et al. Mol Cell Biol, 2010 May. PMID 20160012.
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Ernst R, et al. Mol Cell, 2009 Oct 9. PMID 19818707.
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. Lee JN, et al. J Biol Chem, 2008 Nov 28. PMID 18835813.
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Alexandru G, et al. Cell, 2008 Sep 5. PMID 18775313.
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