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Goat Anti-FSTL1 Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-FSTL1 Antibody AF1445a
    AF1445a (0.3 µg/ml) staining of Placenta lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.chemiluminescence.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q12841
Other Accession NP_009016, 11167
Reactivity Human
Predicted Cow
Host Goat
Clonality Polyclonal
Concentration 0.5mg/ml
Isotype IgG
Additional Information
Other Names Follistatin-related protein 1, Follistatin-like protein 1, FSTL1, FRP
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-FSTL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FSTL1
Synonyms FRP
Function May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).
Cellular Location Secreted.
Tissue Location Overexpressed in synovial tissues from rheumatoid arthritis. EMBL; U06863; AAA66062.1; -; mRNA EMBL; D89937; BAA28707.1; -; mRNA EMBL; AB119283; BAD12167.1; -; Genomic_DNA EMBL; AK289388; BAF82077.1; -; mRNA EMBL; AK291138; BAF83827.1; -; mRNA EMBL; AK300356; BAG62097.1; -; mRNA EMBL; AK312261; BAG35192.1; -; mRNA EMBL; AC063952; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC078982; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471052; EAW79526.1; -; Genomic_DNA EMBL; CH471052; EAW79527.1; -; Genomic_DNA EMBL; BC000055; AAH00055.1; -; mRNA CCDS; CCDS2998.1; -. [Q12841-1] PIR; S51362; S51362 RefSeq; NP_009016.1; NM_007085.4. [Q12841-1] UniGene; Hs.269512; - ProteinModelPortal; Q12841; - SMR; Q12841; - BioGrid; 116338; 40 IntAct; Q12841; 18 MINT; Q12841; - STRING; 9606.ENSP00000295633; - MEROPS; I01.967; - GlyConnect; 1252; - iPTMnet; Q12841; - PhosphoSitePlus; Q12841; - BioMuta; FSTL1; - DMDM; 2498390; - EPD; Q12841; - jPOST; Q12841; - MaxQB; Q12841; - PaxDb; Q12841; - PeptideAtlas; Q12841; - PRIDE; Q12841; - ProteomicsDB; 58980; - Ensembl; ENST00000295633; ENSP00000295633; ENSG00000163430. [Q12841-1] Ensembl; ENST00000424703; ENSP00000394355; ENSG00000163430. [Q12841-2] GeneID; 11167; - KEGG; hsa:11167; - UCSC; uc003eds.4; human. [Q12841-1] CTD; 11167; - DisGeNET; 11167; - EuPathDB; HostDB:ENSG00000163430.9; - GeneCards; FSTL1; - HGNC; HGNC:3972; FSTL1 HPA; HPA035251; - HPA; HPA040815; - MIM; 605547; gene neXtProt; NX_Q12841; - OpenTargets; ENSG00000163430; - PharmGKB; PA28389; - eggNOG; ENOG410IIPU; Eukaryota eggNOG; ENOG410ZJ7W; LUCA GeneTree; ENSGT00940000157784; - HOGENOM; HOG000007780; - HOVERGEN; HBG051665; - InParanoid; Q12841; - OMA; WVHAEEE; - OrthoDB; 1079836at2759; - PhylomeDB; Q12841; - TreeFam; TF106409; - Reactome; R-HSA-201451; Signaling by BMP Reactome; R-HSA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Reactome; R-HSA-8957275; Post-translational protein phosphorylation ChiTaRS; FSTL1; human GeneWiki; FSTL1; - GenomeRNAi; 11167; - PMAP-CutDB; Q12841; - PRO; PR:Q12841; - Proteomes; UP000005640; Chromosome 3 Bgee; ENSG00000163430; Expressed in 226 organ(s), highest expression level in connective tissue ExpressionAtlas; Q12841; baseline and differential Genevisible; Q12841; HS GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0005615; C:extracellular space; HDA:UniProtKB GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:0008201; F:heparin binding; TAS:ProtInc GO; GO:0030509; P:BMP signaling pathway; TAS:Reactome GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome GO; GO:0043687; P:post-translational protein modification; TAS:Reactome GO; GO:0042594; P:response to starvation; IEA:Ensembl Gene3D; 3.90.290.10; -; 1 InterPro; IPR011992; EF-hand-dom_pair InterPro; IPR002048; EF_hand_dom InterPro; IPR003645; Fol_N InterPro; IPR015369; Follistatin/Osteonectin_EGF InterPro; IPR002350; Kazal_dom InterPro; IPR036058; Kazal_dom_sf InterPro; IPR036773; TB_dom_sf Pfam; PF09289; FOLN; 1 Pfam; PF07648; Kazal_2; 1 SMART; SM00274; FOLN; 1 SMART; SM00280; KAZAL; 1 SUPFAM; SSF100895; SSF100895; 1 SUPFAM; SSF47473; SSF47473; 1 PROSITE; PS50222; EF_HAND_2; 2 PROSITE; PS51465; KAZAL_2; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Heparin-binding; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal SIGNAL 1 20 CHAIN 21 308 Follistatin-related protein 1 /FTId=PRO_0000010111 DOMAIN 30 53 Follistatin-like DOMAIN 48 100 Kazal-like. {ECO:0000255|PROSITE- ProRule:PRU00798} DOMAIN 144 178 EF-hand 1. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 193 228 EF-hand 2. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 233 287 VWFC MOD_RES 165 165 Phosphoserine; by FAM20C CARBOHYD 144 144 N-linked (GlcNAc...) asparagine CARBOHYD 175 175 N-linked (GlcNAc...) asparagine CARBOHYD 180 180 N-linked (GlcNAc...) asparagine DISULFID 54 84 {ECO:0000255|PROSITE-ProRule:PRU00798} DISULFID 58 77 {ECO:0000255|PROSITE-ProRule:PRU00798} DISULFID 66 98 {ECO:0000255|PROSITE-ProRule:PRU00798} VAR_SEQ 22 56 Missing (in isoform 2) /FTId=VSP_055075 CONFLICT 221 221 C -> S (in Ref. 4; BAF83827) CONFLICT 226 226 F -> S (in Ref. 4; BAF83827) SEQUENCE 308 AA; 34986 MW; BD4C651FAFF24800 CRC64; MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP TCLCIEQCKP HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE KKSVSPSASP VVCYQSNRDE LRRRIIQWLE AEIIPDGWFS KGSNYSEILD KYFKNFDNGD SRLDSSEFLK FVEQNETAIN ITTYPDQENN KLLRGLCVDA LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY ADGAETEVDC NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT KRVSTKEI
Research Areas
Citations (0)

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Background

This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.

References

MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. Xu Y, et al. Schizophr Res, 2010 Jun. PMID 20347265. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Xu J, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080650. Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma. Clutter SD, et al. J Immunol, 2009 Jan 1. PMID 19109154. Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis. Chan QK, et al. Carcinogenesis, 2009 Jan. PMID 18796737. Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism. Ouchi N, et al. J Biol Chem, 2008 Nov 21. PMID 18718903.

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$ 368.00
Cat# AF1445a
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