|Application ||WB, IHC, E|
|Other Accession||NP_002042, 2625, 14462 (mouse)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||47916 Da|
|Other Names||Trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, GATA3|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GATA3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses.|
|Tissue Location||T-cells and endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287.
GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Yao X, et al. Chin Med J (Engl), 2010 Mar 20. PMID 20368097.
New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.
Lck mediates Th2 differentiation through effects on T-bet and GATA-3. Kemp KL, et al. J Immunol, 2010 Apr 15. PMID 20237292.
GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition. Yan W, et al. J Biol Chem, 2010 Apr 30. PMID 20189993.
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