|Application ||WB, E|
|Other Accession||NP_056151, 23390|
|Predicted||Rat, Dog, Cow|
|Calculated MW||72640 Da|
|Other Names||Palmitoyltransferase ZDHHC17, 126.96.36.199, Huntingtin yeast partner H, Huntingtin-interacting protein 14, HIP-14, Huntingtin-interacting protein 3, HIP-3, Huntingtin-interacting protein H, Putative MAPK-activating protein PM11, Putative NF-kappa-B-activating protein 205, Zinc finger DHHC domain-containing protein 17, DHHC-17, ZDHHC17, HIP14, HIP3, HYPH, KIAA0946|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-HIP14 / ZDHHC17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Palmitoylates MPP1 in erythrocytes (PubMed:22496366). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299).|
|Cellular Location||Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, presynaptic cell membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles|
|Tissue Location||Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
Multiple palmitoyltransferases are required for palmitoylation-dependent regulation of large conductance calcium- and voltage-activated potassium channels. Tian L, et al. J Biol Chem, 2010 Jul 30. PMID 20507996.
Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport. Hines RM, et al. J Biol Chem, 2010 Feb 12. PMID 19955568.
The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Gao T, et al. Proteins, 2009 Aug 15. PMID 19434754.
Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. Goytain A, et al. J Biol Chem, 2008 Nov 28. PMID 18794299.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
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