|Application ||WB, E|
|Other Accession||NP_032378, 16160 (mouse), 64546 (rat)|
|Calculated MW||38235 Da|
|Other Names||Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, Il12b|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Il12b / Il12p40 (mouse) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling. Lindsay RW, et al. J Immunol, 2010 Aug 1. PMID 20610651.
IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. Marshall HD, et al. J Immunol, 2010 Aug 1. PMID 20592282.
IL-12p35 promotes antibody-induced joint inflammation by activating NKT cells and suppressing TGF-beta. Park Y, et al. J Immunol, 2010 Aug 1. PMID 20581146.
Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. Herbert DR, et al. J Immunol, 2010 Jun 1. PMID 20483789.
The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: Insights from a DC vaccination model. Henry CJ, et al. Cell Immunol, 2010. PMID 20483409.
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