|Application ||WB, E|
|Other Accession||NP_660187, 85320|
|Calculated MW||154301 Da|
|Other Names||ATP-binding cassette sub-family C member 11, Multidrug resistance-associated protein 8, ABCC11, MRP8|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MRP8 / ABCC11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Enhances the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S- conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D- glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Vacuole membrane Cytoplasmic vesicle membrane|
|Tissue Location||Expressed in ceruminous apocrine gland (at protein level) (PubMed:19383836, PubMed:19710689). Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.
A functional ABCC11 allele is essential in the biochemical formation of human axillary odor. Martin A, et al. J Invest Dermatol, 2010 Feb. PMID 19710689.
A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene. Nakano M, et al. BMC Genet, 2009 Aug 4. PMID 19650936.
Japanese map of the earwax gene frequency: a nationwide collaborative study by Super Science High School Consortium. Super Science High School Consortium. J Hum Genet, 2009 Sep. PMID 19644513.
Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the Smart Amplification Process (SmartAmp) method. Inoue Y, et al. J Plast Reconstr Aesthet Surg, 2010 Aug. PMID 19625231.
Allele frequencies of the ABCC11 gene for earwax phenotypes among ancient populations of Hokkaido, Japan. Sato T, et al. J Hum Genet, 2009 Jul. PMID 19557017.
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