- CITATIONS: 1
|Application ||WB, IHC, E, EIA|
|Other Accession||NP_002459, 4615, 17874 (mouse), 301059 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||33233 Da|
|Other Names||Myeloid differentiation primary response protein MyD88, MYD88|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-MYD88 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. He B, et al. Nat Immunol, 2010 Sep. PMID 20676093.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Lin SC, et al. Nature, 2010 Jun 17. PMID 20485341.
Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Abu-Maziad A, et al. Pediatr Res, 2010 Oct. PMID 20463618.
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