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Goat Anti-NOVA1 Antibody

Peptide-affinity purified goat antibody

  • IHC - Goat Anti-NOVA1 Antibody AF1740a
    AF1740a (2.5 µg/ml) staining of paraffin embedded Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • WB - Goat Anti-NOVA1 Antibody AF1740a
    AF1740a (0.01 µg/ml) staining of Human Breast Cancer lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • WB - Goat Anti-NOVA1 Antibody AF1740a
    HEK293 overexpressing NOVA1 (RC210407) and probed with AF1740a (mock transfection in first lane), tested by Origene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51513
Other Accession NP_006482, 4857
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Additional Information
Other Names RNA-binding protein Nova-1, Neuro-oncological ventral antigen 1, Onconeural ventral antigen 1, Paraneoplastic Ri antigen, Ventral neuron-specific protein 1, NOVA1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-NOVA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOVA1
Function May regulate RNA splicing or metabolism in a specific subset of developing neurons.
Cellular Location Nucleus.
Tissue Location Brain. EMBL; U04840; AAA16022.1; -; mRNA EMBL; AK289639; BAF82328.1; -; mRNA EMBL; AK291022; BAF83711.1; -; mRNA EMBL; AL079343; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL132716; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471078; EAW65990.1; -; Genomic_DNA EMBL; CH471078; EAW65991.1; -; Genomic_DNA EMBL; CH471078; EAW65992.1; -; Genomic_DNA EMBL; CH471078; EAW65993.1; -; Genomic_DNA EMBL; CH471078; EAW65995.1; -; Genomic_DNA EMBL; BC075038; AAH75038.1; -; mRNA EMBL; BC075039; AAH75039.1; -; mRNA EMBL; Z70771; CAA94810.1; -; mRNA CCDS; CCDS32060.1; -. [P51513-5] CCDS; CCDS32061.1; -. [P51513-4] CCDS; CCDS9635.1; -. [P51513-2] PIR; I38489; I38489 RefSeq; NP_002506.2; NM_002515.2. [P51513-4] RefSeq; NP_006480.2; NM_006489.2. [P51513-5] RefSeq; NP_006482.1; NM_006491.2. [P51513-2] UniGene; Hs.31588; - PDB; 1DT4; X-ray; 2.60 A; A=424-495 PDB; 2ANN; X-ray; 2.30 A; A=49-249 PDB; 2ANR; X-ray; 1.94 A; A=49-249 PDBsum; 1DT4; - PDBsum; 2ANN; - PDBsum; 2ANR; - ProteinModelPortal; P51513; - SMR; P51513; - BioGrid; 110919; 10 IntAct; P51513; 8 MINT; P51513; - STRING; 9606.ENSP00000438875; - iPTMnet; P51513; - PhosphoSitePlus; P51513; - BioMuta; NOVA1; - DMDM; 1709303; - EPD; P51513; - MaxQB; P51513; - PaxDb; P51513; - PeptideAtlas; P51513; - PRIDE; P51513; - ProteomicsDB; 56315; - ProteomicsDB; 56316; -. [P51513-2] ProteomicsDB; 56317; -. [P51513-3] ProteomicsDB; 56318; -. [P51513-4] TopDownProteomics; P51513-2; -. [P51513-2] Ensembl; ENST00000344429; ENSP00000342387; ENSG00000139910. [P51513-2] Ensembl; ENST00000465357; ENSP00000447391; ENSG00000139910. [P51513-5] Ensembl; ENST00000539517; ENSP00000438875; ENSG00000139910. [P51513-4] GeneID; 4857; - KEGG; hsa:4857; - UCSC; uc001wpy.4; human. [P51513-1] CTD; 4857; - DisGeNET; 4857; - EuPathDB; HostDB:ENSG00000139910.19; - GeneCards; NOVA1; - H-InvDB; HIX0037755; - HGNC; HGNC:7886; NOVA1 HPA; HPA004155; - MIM; 602157; gene neXtProt; NX_P51513; - OpenTargets; ENSG00000139910; - PharmGKB; PA31688; - eggNOG; KOG2191; Eukaryota eggNOG; ENOG410XRZD; LUCA GeneTree; ENSGT00760000119144; - HOGENOM; HOG000007833; - HOVERGEN; HBG082048; - InParanoid; P51513; - KO; K14944; - OMA; VVDFIMD; - OrthoDB; EOG091G185U; - PhylomeDB; P51513; - TreeFam; TF316981; - ChiTaRS; NOVA1; human EvolutionaryTrace; P51513; - GeneWiki; NOVA1; - GenomeRNAi; 4857; - PRO; PR:P51513; - Proteomes; UP000005640; Chromosome 14 Bgee; ENSG00000139910; - CleanEx; HS_NOVA1; - ExpressionAtlas; P51513; baseline and differential Genevisible; P51513; HS GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA GO; GO:0005730; C:nucleolus; IDA:HPA GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0003729; F:mRNA binding; IEA:Ensembl GO; GO:0003723; F:RNA binding; HDA:UniProtKB GO; GO:0007268; P:chemical synaptic transmission; TAS:ProtInc GO; GO:0007626; P:locomotory behavior; TAS:ProtInc GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl GO; GO:0051252; P:regulation of RNA metabolic process; IEA:Ensembl GO; GO:0006396; P:RNA processing; TAS:ProtInc GO; GO:0008380; P:RNA splicing; TAS:ProtInc Gene3D; 3.30.1370.10; -; 3 InterPro; IPR004087; KH_dom InterPro; IPR004088; KH_dom_type_1 InterPro; IPR036612; KH_dom_type_1_sf InterPro; IPR033086; NOVA1 PANTHER; PTHR10288:SF223; PTHR10288:SF223; 1 Pfam; PF00013; KH_1; 3 SMART; SM00322; KH; 3 SUPFAM; SSF54791; SSF54791; 3 PROSITE; PS50084; KH_TYPE_1; 3 1: Evidence at protein level; 3D-structure; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding CHAIN 1 510 RNA-binding protein Nova-1 /FTId=PRO_0000050116 DOMAIN 49 119 KH 1. {ECO:0000255|PROSITE- ProRule:PRU00117} DOMAIN 174 240 KH 2. {ECO:0000255|PROSITE- ProRule:PRU00117} DOMAIN 424 491 KH 3. {ECO:0000255|PROSITE- ProRule:PRU00117} MOTIF 27 43 Bipartite nuclear localization signal COMPBIAS 276 412 Ala-rich MOD_RES 157 157 Phosphoserine {ECO:0000250|UniProtKB:Q9JKN6} VAR_SEQ 88 90 Missing (in isoform 2, isoform 4 and isoform 5). /FTId=VSP_002841 VAR_SEQ 153 176 Missing (in isoform 3 and isoform 5) /FTId=VSP_002842 VAR_SEQ 177 184 VKIIVPNS -> KHNISWIS (in isoform 2) /FTId=VSP_002843 VAR_SEQ 185 510 Missing (in isoform 2) /FTId=VSP_002844 STRAND 50 57 {ECO:0000244|PDB:2ANR} HELIX 58 65 {ECO:0000244|PDB:2ANR} HELIX 67 69 {ECO:0000244|PDB:2ANR} HELIX 70 79 {ECO:0000244|PDB:2ANR} STRAND 82 85 {ECO:0000244|PDB:2ANR} STRAND 98 107 {ECO:0000244|PDB:2ANR} HELIX 109 123 {ECO:0000244|PDB:2ANR} HELIX 148 151 {ECO:0000244|PDB:2ANR} STRAND 177 182 {ECO:0000244|PDB:2ANR} HELIX 183 190 {ECO:0000244|PDB:2ANR} HELIX 192 194 {ECO:0000244|PDB:2ANR} HELIX 195 203 {ECO:0000244|PDB:2ANR} STRAND 207 210 {ECO:0000244|PDB:2ANR} STRAND 221 229 {ECO:0000244|PDB:2ANR} HELIX 230 245 {ECO:0000244|PDB:2ANR} STRAND 425 432 {ECO:0000244|PDB:1DT4} TURN 433 436 {ECO:0000244|PDB:1DT4} HELIX 437 440 {ECO:0000244|PDB:1DT4} HELIX 442 444 {ECO:0000244|PDB:1DT4} HELIX 445 454 {ECO:0000244|PDB:1DT4} STRAND 457 460 {ECO:0000244|PDB:1DT4} STRAND 472 479 {ECO:0000244|PDB:1DT4} HELIX 481 494 {ECO:0000244|PDB:1DT4} SEQUENCE 510 AA; 52056 MW; 7B9BA8B67CAB6984 CRC64; MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY FLKVLIPSYA AGSIIGKGGQ TIVQLQKETG ATIKLSKLSK SKDFYPGTTE RVCLIQGTVE ALNAVHGFIA EKIREMPQNV AKTEPVSILQ PQTTVNPDRI KQTLPSSPTT TKSSPSDPMT TSRANQVKII VPNSTAGLII GKGGATVKAV MEQSGAWVQL SQKPDGINLQ ERVVTVSGEP EQNRKAVELI IQKIQEDPQS GSCLNISYAN VTGPVANSNP TGSPYANTAE VLPTAAAAAG LLGHANLAGV AAFPAVLSGF TGNDLVAITS ALNTLASYGY NLNTLGLGLS QAAATGALAA AAASANPAAA AANLLATYAS EASASGSTAG GTAGTFALGS LAAATAATNG YFGAASPLAA SAILGTEKST DGSKDVVEIA VPENLVGAIL GKGGKTLVEY QELTGARIQI SKKGEFVPGT RNRKVTITGT PAATQAAQYL ITQRITYEQG VRAANPQKVG
Research Areas
Citations (0)

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This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.


Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients. Alkelai A, et al. Psychopharmacology (Berl), 2009 Oct. PMID 19680635.
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. Vasan RS, et al. JAMA, 2009 Jul 8. PMID 19584346.
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. Anney RJ, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18951430.
Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome. Stich O, et al. Acta Neurol Scand, 2009 May. PMID 18822086.
Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. Ratti A, et al. J Biol Chem, 2008 Mar 21. PMID 18218628.

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$ 368.00
Cat# AF1740a
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