|Application ||WB, E|
|Other Accession||NP_002657, 5346|
|Calculated MW||55990 Da|
|Other Names||Perilipin-1, Lipid droplet-associated protein, PLIN1, PERI, PLIN|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Perilipin (internal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.|
|Cellular Location||Endoplasmic reticulum. Lipid droplet Note=Lipid droplet surface-associated|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene.
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Rua帽o G, et al. Pharmacogenomics, 2010 Jul. PMID 20602615.
Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males. Sone Y, et al. J Nutr Sci Vitaminol (Tokyo), 2010. PMID 20495294.
Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.
Perilipin gene 1237 T > C polymorphism is not associated with obesity risk in northern Chinese Han adults. Hu DS, et al. Biomed Environ Sci, 2009 Oct. PMID 20163070.
Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning. Fujii H, et al. J Atheroscler Thromb, 2009. PMID 20032580.
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