|Application ||WB, IHC, E|
|Other Accession||NP_473429, 80339, 116939 (mouse), 362972 (rat)|
|Predicted||Rat, Pig, Dog|
|Calculated MW||52865 Da|
|Other Names||Patatin-like phospholipase domain-containing protein 3, 188.8.131.52, Acylglycerol O-acyltransferase, 2.3.1.-, Adiponutrin, Calcium-independent phospholipase A2-epsilon, iPLA2-epsilon, PNPLA3, ADPN, C22orf20|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-PNPLA3 / Adiponutrin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221).|
|Cellular Location||Membrane; Single-pass type II membrane protein. Lipid droplet|
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