|Application ||WB, IHC, E|
|Other Accession||NP_002890, 5947|
|Calculated MW||15850 Da|
|Other Names||Retinol-binding protein 1, Cellular retinol-binding protein, CRBP, Cellular retinol-binding protein I, CRBP-I, RBP1, CRBP1|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-RBP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496).|
|Cellular Location||Cytoplasm. Lipid droplet|
|Tissue Location||Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland and adrenal gland, and fetal liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Lipkin SM, et al. Cancer Prev Res (Phila), 2010 May. PMID 20403997.
New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers. Franzoni L, et al. J Lipid Res, 2010 Jun. PMID 19965581.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma. Tsunoda S, et al. Oncol Rep, 2009 Apr. PMID 19288010.
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