|Application ||WB, IHC, E|
|Other Accession||NP_002825, 5781, 19247 (mouse), 25622 (rat)|
|Predicted||Rat, Pig, Cow|
|Calculated MW||68436 Da|
|Other Names||Tyrosine-protein phosphatase non-receptor type 11, 22.214.171.124, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SHP2 / PTPN11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed, with highest levels in heart, brain, and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
[Expression and its clinical significance of SHP2 in non-small cell lung cancer] Tang C, et al. Zhongguo Fei Ai Za Zhi, 2010 Feb. PMID 20673499.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.
The language phenotype of children and adolescents with Noonan syndrome. Pierpont EI, et al. J Speech Lang Hear Res, 2010 Aug. PMID 20543023.
Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses. Chen W, et al. J Cell Biochem, 2010 Jun 1. PMID 20512931.
Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression. Wang Q, et al. J Biol Chem, 2010 Jul 16. PMID 20472558.
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