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Goat Anti-Swiprosin 1 / EFHD2 Antibody

Peptide-affinity purified goat antibody

  • WB - Goat Anti-Swiprosin 1 / EFHD2 Antibody AF2054a
    AF2054a (0.1 µg/ml) staining of human lymph node lysate. Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-Swiprosin 1 / EFHD2 Antibody AF2054a
    B6552 (2 µg/ml) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96C19
Other Accession NP_077305, 79180, 27984 (mouse)
Reactivity Human, Mouse
Predicted Rat, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Additional Information
Other Names EF-hand domain-containing protein D2, Swiprosin-1, EFHD2, SWS1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-Swiprosin 1 / EFHD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EFHD2
Synonyms SWS1
Function May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Cellular Location Membrane raft. Note=In a mouse immature B-cell line WEHI-231.
Tissue Location Found in lymphocytes; preferentially expressed in CD8+ cells. EMBL; AL031283; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471167; EAW51720.1; -; Genomic_DNA EMBL; BC007233; AAH07233.1; -; mRNA EMBL; BC014923; AAH14923.1; -; mRNA EMBL; BC023611; AAH23611.1; -; mRNA EMBL; BC068473; AAH68473.1; -; mRNA CCDS; CCDS155.1; - RefSeq; NP_077305.2; NM_024329.5 UniGene; Hs.465374; - PDB; 5H0P; X-ray; 1.86 A; A=70-184 PDB; 5I2L; X-ray; 1.85 A; A=70-184 PDB; 5I2O; X-ray; 1.95 A; A=70-184 PDB; 5I2Q; X-ray; 1.94 A; A=70-184 PDBsum; 5H0P; - PDBsum; 5I2L; - PDBsum; 5I2O; - PDBsum; 5I2Q; - ProteinModelPortal; Q96C19; - SMR; Q96C19; - BioGrid; 122597; 47 IntAct; Q96C19; 7 MINT; Q96C19; - STRING; 9606.ENSP00000365147; - iPTMnet; Q96C19; - PhosphoSitePlus; Q96C19; - SwissPalm; Q96C19; - BioMuta; EFHD2; - DMDM; 20140139; - REPRODUCTION-2DPAGE; IPI00060181; - SWISS-2DPAGE; Q96C19; - EPD; Q96C19; - MaxQB; Q96C19; - PaxDb; Q96C19; - PeptideAtlas; Q96C19; - PRIDE; Q96C19; - ProteomicsDB; 76150; - TopDownProteomics; Q96C19; - Ensembl; ENST00000375980; ENSP00000365147; ENSG00000142634 GeneID; 79180; - KEGG; hsa:79180; - UCSC; uc001awh.2; human CTD; 79180; - DisGeNET; 79180; - EuPathDB; HostDB:ENSG00000142634.12; - GeneCards; EFHD2; - HGNC; HGNC:28670; EFHD2 HPA; HPA048961; - MIM; 616450; gene neXtProt; NX_Q96C19; - OpenTargets; ENSG00000142634; - PharmGKB; PA134942316; - eggNOG; KOG0041; Eukaryota eggNOG; ENOG4111JG9; LUCA GeneTree; ENSGT00390000012058; - HOGENOM; HOG000007978; - HOVERGEN; HBG051446; - InParanoid; Q96C19; - OMA; QYDAGKD; - OrthoDB; EOG091G106K; - PhylomeDB; Q96C19; - TreeFam; TF320736; - ChiTaRS; EFHD2; human GenomeRNAi; 79180; - PRO; PR:Q96C19; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000142634; - CleanEx; HS_EFHD2; - ExpressionAtlas; Q96C19; baseline and differential Genevisible; Q96C19; HS GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL GO; GO:0005509; F:calcium ion binding; IEA:InterPro CDD; cd00051; EFh; 1 InterPro; IPR011992; EF-hand-dom_pair InterPro; IPR002048; EF_hand_dom Pfam; PF13499; EF-hand_7; 1 SMART; SM00054; EFh; 2 SUPFAM; SSF47473; SSF47473; 1 PROSITE; PS50222; EF_HAND_2; 2 1: Evidence at protein level; 3D-structure; Acetylation; Calcium; Complete proteome; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat INIT_MET 1 1 Removed. {ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:22814378, ECO:0000269|Ref.4} CHAIN 2 240 EF-hand domain-containing protein D2 /FTId=PRO_0000073645 DOMAIN 92 127 EF-hand 1. {ECO:0000255|PROSITE- ProRule:PRU00448} DOMAIN 128 163 EF-hand 2. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 105 116 1. {ECO:0000255|PROSITE- ProRule:PRU00448} CA_BIND 141 152 2. {ECO:0000255|PROSITE- ProRule:PRU00448} MOD_RES 2 2 N-acetylalanine {ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:22814378, ECO:0000269|Ref.4} MOD_RES 11 11 Phosphoserine MOD_RES 74 74 Phosphoserine MOD_RES 76 76 Phosphoserine MOD_RES 83 83 Phosphotyrosine {ECO:0000250|UniProtKB:Q9D8Y0} MOD_RES 233 233 N6-acetyllysine HELIX 82 85 {ECO:0000244|PDB:5I2L} HELIX 91 104 {ECO:0000244|PDB:5I2L} STRAND 109 112 {ECO:0000244|PDB:5I2L} HELIX 114 124 {ECO:0000244|PDB:5I2L} HELIX 130 140 {ECO:0000244|PDB:5I2L} STRAND 145 149 {ECO:0000244|PDB:5I2L} HELIX 150 161 {ECO:0000244|PDB:5I2L} HELIX 170 177 {ECO:0000244|PDB:5I2L} SEQUENCE 240 AA; 26697 MW; 9FE3FEC3007A8FC2 CRC64; MATDELATKL SRRLQMEGEG GGETPEQPGL NGAAAAAAGA PDEAAEALGS ADCELSAKLL RRADLNQGIG EPQSPSRRVF NPYTEFKEFS RKQIKDMEKM FKQYDAGRDG FIDLMELKLM MEKLGAPQTH LGLKNMIKEV DEDFDSKLSF REFLLIFRKA AAGELQEDSG LCVLARLSEI DVSSEGVKGA KSFFEAKVQA INVSSRFEEE IKAEQEERKK QAEEMKQRKA AFKELQSTFK
Research Areas
Citations (0)

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Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030.
Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway. Thylur RP, et al. J Cell Biochem, 2009 Oct 15. PMID 19693767.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.
The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis. Avramidou A, et al. Cell Death Differ, 2007 Nov. PMID 17673920.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.

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$ 368.00
Cat# AF2054a
Availability: 7-10 days
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