|Application ||WB, E|
|Other Accession||NP_001087240, 7296|
|Calculated MW||70906 Da|
|Other Names||Thioredoxin reductase 1, cytoplasmic, TR, 188.8.131.52, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Thioredoxin Reductase 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.|
|Cellular Location||Cytoplasm. Isoform 5: Cytoplasm.|
|Tissue Location||Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver|
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This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets. Turanov AA, et al. Biochem J, 2010 Sep 1. PMID 20536427.
Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells. Javvadi P, et al. Cancer Res, 2010 Mar 1. PMID 20160040.
Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic. Engstr枚m KS, et al. Mutat Res, 2010 Jan 5. PMID 19896490.
Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence. Volonte D, et al. EMBO Rep, 2009 Dec. PMID 19820694.
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy. Eriksson SE, et al. Free Radic Biol Med, 2009 Dec 1. PMID 19766715.
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