|Application ||WB, IHC, E|
|Other Accession||NP_061838, 54209|
|Calculated MW||25447 Da|
|Other Names||Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, TREM2|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TREM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL).
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. Koth LL, et al. J Immunol, 2010 Jun 1. PMID 20421649.
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.
The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. Stefano L, et al. J Neurochem, 2009 Jul. PMID 19457124.
TREM and TREM-like receptors in inflammation and disease. Ford JW, et al. Curr Opin Immunol, 2009 Feb. PMID 19230638.
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