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Goat Anti-TXNDC1 / TMX Antibody

Peptide-affinity purified goat antibody

     
  • WB - Goat Anti-TXNDC1 / TMX Antibody AF2125a
    AF2125a (0.01 µg/ml) staining of human liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • IHC - Goat Anti-TXNDC1 / TMX Antibody AF2125a
    AF2125a (3.8 µg/ml) staining of paraffin embedded Human Spleen Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession Q9H3N1
Other Accession NP_110382, 81542
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 100ug/200ul
Isotype IgG
Additional Information
Other Names Thioredoxin-related transmembrane protein 1, Thioredoxin domain-containing protein 1, Transmembrane Trx-related protein, TMX1, TMX, TXNDC, TXNDC1
Format 0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TXNDC1 / TMX Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMX1
Synonyms TMX, TXNDC, TXNDC1
Function May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
Cellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein Note=Predominantly found in the endoplasmic reticulum
Tissue Location Ubiquitous. Highly expressed in kidney, liver, placenta and lung EMBL; AB048246; BAB20629.1; -; mRNA EMBL; AY358640; AAQ89003.1; -; mRNA EMBL; AK075395; BAC11593.1; -; mRNA EMBL; AK312905; BAG35751.1; -; mRNA EMBL; AL080080; CAB45700.2; -; mRNA EMBL; AL591807; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471078; EAW65678.1; -; Genomic_DNA EMBL; BC036460; AAH36460.1; -; mRNA EMBL; BC056874; AAH56874.2; -; mRNA CCDS; CCDS41953.1; - PIR; T12471; T12471 RefSeq; NP_110382.3; NM_030755.4 UniGene; Hs.125221; - PDB; 1X5E; NMR; -; A=30-142 PDBsum; 1X5E; - ProteinModelPortal; Q9H3N1; - SMR; Q9H3N1; - BioGrid; 123510; 62 IntAct; Q9H3N1; 34 MINT; Q9H3N1; - STRING; 9606.ENSP00000393316; - iPTMnet; Q9H3N1; - PhosphoSitePlus; Q9H3N1; - SwissPalm; Q9H3N1; - BioMuta; TMX1; - DMDM; 47117631; - EPD; Q9H3N1; - jPOST; Q9H3N1; - MaxQB; Q9H3N1; - PaxDb; Q9H3N1; - PeptideAtlas; Q9H3N1; - PRIDE; Q9H3N1; - ProteomicsDB; 80733; - TopDownProteomics; Q9H3N1; - DNASU; 81542; - Ensembl; ENST00000457354; ENSP00000393316; ENSG00000139921 GeneID; 81542; - KEGG; hsa:81542; - UCSC; uc001wza.5; human CTD; 81542; - EuPathDB; HostDB:ENSG00000139921.12; - GeneCards; TMX1; - HGNC; HGNC:15487; TMX1 HPA; HPA003085; - MIM; 610527; gene neXtProt; NX_Q9H3N1; - OpenTargets; ENSG00000139921; - PharmGKB; PA37968; - eggNOG; KOG0913; Eukaryota eggNOG; ENOG4111H66; LUCA GeneTree; ENSGT00940000155959; - HOGENOM; HOG000045750; - InParanoid; Q9H3N1; - OMA; IPSWASY; - OrthoDB; 1481386at2759; - PhylomeDB; Q9H3N1; - TreeFam; TF106376; - ChiTaRS; TMX1; human EvolutionaryTrace; Q9H3N1; - GeneWiki; TMX1; - GenomeRNAi; 81542; - PRO; PR:Q9H3N1; - Proteomes; UP000005640; Chromosome 14 Bgee; ENSG00000139921; Expressed in 237 organ(s), highest expression level in tibia ExpressionAtlas; Q9H3N1; baseline and differential Genevisible; Q9H3N1; HS GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0015036; F:disulfide oxidoreductase activity; IDA:UniProtKB GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro GO; GO:0034976; P:response to endoplasmic reticulum stress; IMP:UniProtKB InterPro; IPR036249; Thioredoxin-like_sf InterPro; IPR017937; Thioredoxin_CS InterPro; IPR013766; Thioredoxin_domain Pfam; PF00085; Thioredoxin; 1 SUPFAM; SSF52833; SSF52833; 1 PROSITE; PS00194; THIOREDOXIN_1; 1 PROSITE; PS51352; THIOREDOXIN_2; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Disulfide bond; Electron transport; Endoplasmic reticulum; Membrane; Phosphoprotein; Redox-active center; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport SIGNAL 1 26 CHAIN 27 280 Thioredoxin-related transmembrane protein 1 /FTId=PRO_0000034153 TOPO_DOM 27 180 Extracellular. TRANSMEM 181 203 Helical. TOPO_DOM 204 280 Cytoplasmic. DOMAIN 27 132 Thioredoxin. {ECO:0000255|PROSITE- ProRule:PRU00691} MOD_RES 228 228 Phosphoserine MOD_RES 247 247 Phosphoserine MOD_RES 270 270 Phosphoserine MOD_RES 274 274 Phosphoserine MOD_RES 280 280 Phosphoserine DISULFID 56 59 Redox-active. {ECO:0000255|PROSITE- ProRule:PRU00691, ECO:0000269|PubMed:11152479} MUTAGEN 56 56 C->S: Loss of reductase activity; when associated with S-59 MUTAGEN 59 59 C->S: Loss of reductase activity; when associated with S-56 CONFLICT 14 16 LVL -> MVP (in Ref. 8; AAH36460) CONFLICT 98 98 T -> N (in Ref. 8; AAH36460) CONFLICT 177 177 V -> A (in Ref. 4; BAC11593) STRAND 30 33 {ECO:0000244|PDB:1X5E} TURN 36 38 {ECO:0000244|PDB:1X5E} HELIX 39 42 {ECO:0000244|PDB:1X5E} STRAND 44 52 {ECO:0000244|PDB:1X5E} HELIX 57 73 {ECO:0000244|PDB:1X5E} HELIX 74 76 {ECO:0000244|PDB:1X5E} STRAND 79 84 {ECO:0000244|PDB:1X5E} TURN 85 87 {ECO:0000244|PDB:1X5E} HELIX 89 94 {ECO:0000244|PDB:1X5E} STRAND 99 107 {ECO:0000244|PDB:1X5E} STRAND 110 113 {ECO:0000244|PDB:1X5E} HELIX 120 128 {ECO:0000244|PDB:1X5E} HELIX 131 134 {ECO:0000244|PDB:1X5E} SEQUENCE 280 AA; 31791 MW; A57E222481A997DE CRC64; MAPSGSLAVP LAVLVLLLWG APWTHGRRSN VRVITDENWR ELLEGDWMIE FYAPWCPACQ NLQPEWESFA EWGEDLEVNI AKVDVTEQPG LSGRFIITAL PTIYHCKDGE FRRYQGPRTK KDFINFISDK EWKSIEPVSS WFGPGSVLMS SMSALFQLSM WIRTCHNYFI EDLGLPVWGS YTVFALATLF SGLLLGLCMI FVADCLCPSK RRRPQPYPYP SKKLLSESAQ PLKKVEEEQE ADEEDVSEEE AESKEGTNKD FPQNAIRQRS LGPSLATDKS
Research Areas
Citations (0)

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Background

TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001 [PubMed 11152479]).

References

Physical and functional interaction of transmembrane thioredoxin-related protein with major histocompatibility complex class I heavy chain: redox-based protein quality control and its potential relevance to immune responses. Matsuo Y, et al. Mol Biol Cell, 2009 Nov. PMID 19741092.
Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743.

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$ 368.00
Cat# AF2125a
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