|Application ||WB, E|
|Other Accession||NP_848597, 196403, 80904 (mouse), 500847 (rat)|
|Predicted||Human, Rat, Cow|
|Calculated MW||37988 Da|
|Other Names||Probable E3 ubiquitin-protein ligase DTX3, 6.3.2.-, Protein deltex-3, Deltex3, RING finger protein 154, DTX3, RNF154|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-DTX3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.|
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Provided below are standard protocols that you may find useful for product applications.
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. Chastagner P, et al. EMBO Rep, 2006 Nov. PMID 17028573.
Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. Takeyama K, et al. J Biol Chem, 2003 Jun 13. PMID 12670957.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Kishi N, et al. Int J Dev Neurosci, 2001 Feb. PMID 11226752.
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