|Application ||WB, E|
|Other Accession||NP_001007233, 440068|
|Calculated MW||11868 Da|
|Other Names||Caspase recruitment domain-containing protein 17, Caspase-1 inhibitor INCA, Inhibitory caspase recruitment domain protein, CARD17, INCA|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-INCA / CARD17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.|
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Provided below are standard protocols that you may find useful for product applications.
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. Lamkanfi M, et al. J Biol Chem, 2004 Dec 10. PMID 15383541.
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