|Application ||WB, E|
|Other Accession||NP_219493, 85458, 330938 (mouse), 363062 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||77478 Da|
|Other Names||Dixin, Coiled-coil protein DIX1, Coiled-coil-DIX1, DIX domain-containing protein 1, DIXDC1, CCD1, KIAA1735|
|Format||0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-DIXDC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.|
|Cellular Location||Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis (PubMed:19375513). Associated with actin stress fiber at the filament ends (PubMed:16814745).|
|Tissue Location||Ubiquitously expressed with higher expression in cardiac and skeletal muscles.|
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Provided below are standard protocols that you may find useful for product applications.
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Singh KK, et al. Neuron, 2010 Jul 15. PMID 20624590.
Wnt signaling stabilizes the DIXDC1 protein through decreased ubiquitin-dependent degradation. Wang L, et al. Cancer Sci, 2010 Mar. PMID 20085589.
DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation. Wang L, et al. Cancer Sci, 2009 Oct. PMID 19572978.
DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293 cells. Wu Y, et al. Cell Biol Int, 2009 Jun. PMID 19375513.
DIXDC1 promotes retinoic acid-induced neuronal differentiation and inhibits gliogenesis in P19 cells. Jing XT, et al. Cell Mol Neurobiol, 2009 Feb. PMID 18629627.
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