|Application ||WB, E|
|Other Accession||NP_002591.2, NP_001032416.1, NP_001032417.1, 5142, 18578 (mouse)|
|Calculated MW||83343 Da|
|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 4B, 22.214.171.124, DPDE4, PDE32, PDE4B, DPDE4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDE4B Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.|
|Tissue Location||Expressed in brain, heart, lung and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize all reported isoforms (NP_002591.2; NP_001032416.1; NP_001032417.1).
Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma. Kim SW, Rai D, Aguiar RC. Clin Cancer Res. 2011 Nov 1;17(21):6723-32. PMID: 21742807
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