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MTMR9 (C Terminus) Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q96QG7 |
| Other Accession | NP_056273.2, 66036 |
| Reactivity | Rat |
| Predicted | Human, Mouse, Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 63462 Da |
| Gene ID | 66036 |
|---|---|
| Other Names | Myotubularin-related protein 9, MTMR9, C8orf9, MTMR8 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTMR9 (C Terminus) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTMR9 |
|---|---|
| Synonyms | C8orf9, MTMR8 |
| Function | Acts as an adapter for myotubularin-related phosphatases (PubMed:19038970, PubMed:22647598). Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (PubMed:19038970, PubMed:22647598). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate (PubMed:22647598). The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). Stabilizes MTMR8 protein levels (PubMed:22647598). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6- mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Negatively regulates autophagy, in part via its association with MTMR8 (PubMed:22647598). Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 (PubMed:19038970, PubMed:22647598). Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (PubMed:19038970). |
| Cellular Location | Cytoplasm. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9Z2D0}; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR6 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970) {ECO:0000250|UniProtKB:Q9Z2D0, ECO:0000269|PubMed:19038970} |
| Tissue Location | Expressed in many tissues. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23. Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC. Genomics. 2001 Jul;75(1-3):6-8. PMID: 11472061
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$ 368.00
Cat# AF2246a
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