|Application ||WB, E|
|Other Accession||NP_054730.1, 9655, 56468 (mouse)|
|Predicted||Mouse, Rat, Pig, Cow|
|Calculated MW||61246 Da|
|Other Names||Suppressor of cytokine signaling 5, SOCS-5, Cytokine-inducible SH2 protein 6, CIS-6, Cytokine-inducible SH2-containing protein 5, SOCS5, CIS6, CISH5, CISH6, KIAA0671|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOCS5 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CIS6, CISH5, CISH6, KIAA0671|
|Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.|
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Provided below are standard protocols that you may find useful for product applications.
Both reported variants represent identical protein: NP_054730.1 and NP_659198.1.
Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization. Magrangeas F, Apiou F, Denis S, Weidle U, Jacques Y, Minvielle S. Cytogenet Cell Genet. 2000;88(1-2):78-81. PMID: 10773671
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