|Application ||IHC, E|
|Other Accession||NP_036274.3, NP_411241.1, 23582|
|Calculated MW||40262 Da|
|Other Names||Cyclin-D1-binding protein 1, Grap2 and cyclin-D-interacting protein, Human homolog of Maid, CCNDBP1, DIP1, GCIP, HHM|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GCIP / MAID Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DIP1, GCIP, HHM|
|Function||May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise both human isoforms of this protein.
GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M. J Biol Chem. 2000 Jul 7;275(27):20942-8. PMID: 10801854
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