|Application ||WB, E|
|Other Accession||NP_006615.2, NP_997644.2, NP_001189393.1, NP_001189394.1, NP_001189395.1, NP_001189396.1, NP_001189397.1, 10771, 66505 (mouse)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||70963 Da|
|Other Names||Zinc finger MYND domain-containing protein 11, Adenovirus 5 E1A-binding protein, Bone morphogenetic protein receptor-associated molecule 1, Protein BS69, ZMYND11, BRAM1, BS69|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BS69 / ZMYND11 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non- specifically to dsDNA (PubMed:24675531). Acts as a tumor- suppressor by repressing a transcriptional program essential for tumor cell growth.|
|Cellular Location||Nucleus Chromosome. Note=Associates with chromatin and mitotic chromosomes.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognise all reported human isoforms (NP_006615.2; NP_997644.2; NP_001189393.1; NP_001189394.1; NP_001189395.1; NP_001189396.1; NP_001189397.1).
BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation. Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R. EMBO J. 1995 Jul 3;14(13):3159-69. PMID: 7621829
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