|Application ||IHC, E|
|Other Accession||NP_112174.2, 81603, 93679 (mouse)|
|Predicted||Mouse, Rat, Pig, Dog|
|Calculated MW||61489 Da|
|Other Names||Probable E3 ubiquitin-protein ligase TRIM8, 6.3.2.-, Glioblastoma-expressed RING finger protein, RING finger protein 27, Tripartite motif-containing protein 8, TRIM8, GERP, RNF27|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GERP / TRIM8 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which plays different roles in immune pathways. Participates in the activation of interferon- gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'lys-63' polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148).|
|Cellular Location||Cytoplasm. Nucleus. Note=Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
A novel RING finger-B box-coiled-coil protein, GERP. Vincent SR, Kwasnicka DA, Fretier P. Biochem Biophys Res Commun. 2000 Dec 20;279(2):482-6. PMID: 11118312
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