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GERP / TRIM8 Antibody (C-Term)

Peptide-affinity purified goat antibody

     
  • IHC - GERP / TRIM8 Antibody (C-Term) AF2319a
    AF2319a (4 µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession Q9BZR9
Other Accession NP_112174.2, 81603, 93679 (mouse)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 61489 Da
Additional Information
Gene ID 81603
Other Names Probable E3 ubiquitin-protein ligase TRIM8, 6.3.2.-, Glioblastoma-expressed RING finger protein, RING finger protein 27, Tripartite motif-containing protein 8, TRIM8, GERP, RNF27
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGERP / TRIM8 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM8
Synonyms GERP, RNF27
Function E3 ubiquitin-protein ligase which plays different roles in immune pathways. Participates in the activation of interferon- gamma signaling by promoting proteasomal degradation of the repressor SOCS1 (PubMed:12163497). Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'lys-63' polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B (PubMed:22084099, PubMed:23152791). Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus (PubMed:20516148).
Cellular Location Cytoplasm. Nucleus. Note=Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B
Tissue Location Widely expressed.
Research Areas
Citations (0)

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References

A novel RING finger-B box-coiled-coil protein, GERP. Vincent SR, Kwasnicka DA, Fretier P. Biochem Biophys Res Commun. 2000 Dec 20;279(2):482-6. PMID: 11118312

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$ 368.00
Cat# AF2319a
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