|Application ||WB, E|
|Other Accession||NP_619645.1, 135644|
|Calculated MW||29336 Da|
|Other Names||Tripartite motif-containing protein 40, Probable E3 NEDD8-protein ligase, RING finger protein 35, TRIM40, RNF35|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNF35 / TRIM40 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.|
|Tissue Location||Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.|
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Provided below are standard protocols that you may find useful for product applications.
The RING finger. A novel protein sequence motif related to the zinc finger. Freemont PS. Ann N Y Acad Sci. 1993 Jun 11;684:174-92. Review. No abstract available. PMID: 8317827
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