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FOXB1 / FKH5 Antibody (C-Term)

Peptide-affinity purified goat antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, ICC, E
Primary Accession Q99853
Other Accession NP_036314.2, 27023, 64290 (mouse)
Reactivity Mouse
Predicted Human, Rat, Pig, Dog, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Additional Information
Other Names Forkhead box protein B1, Transcription factor FKH-5, FOXB1, FKH5
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOXB1 / FKH5 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXB1
Synonyms FKH5
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089} EMBL; AF071554; AAC62493.1; -; mRNA EMBL; AF055080; AAC09344.1; -; Genomic_DNA EMBL; AK290944; BAF83633.1; -; mRNA EMBL; CH471082; EAW77581.1; -; Genomic_DNA EMBL; BC113710; AAI13711.1; -; mRNA EMBL; U87393; AAB47564.1; -; mRNA CCDS; CCDS32255.1; - RefSeq; NP_036314.2; NM_012182.2 UniGene; Hs.734475; - ProteinModelPortal; Q99853; - SMR; Q99853; - BioGrid; 117960; 133 IntAct; Q99853; 128 MINT; Q99853; - STRING; 9606.ENSP00000379369; - iPTMnet; Q99853; - PhosphoSitePlus; Q99853; - BioMuta; FOXB1; - DMDM; 215274160; - PaxDb; Q99853; - PRIDE; Q99853; - ProteomicsDB; 78505; - Ensembl; ENST00000396057; ENSP00000379369; ENSG00000171956 GeneID; 27023; - KEGG; hsa:27023; - UCSC; uc002agj.2; human CTD; 27023; - DisGeNET; 27023; - EuPathDB; HostDB:ENSG00000171956.6; - GeneCards; FOXB1; - HGNC; HGNC:3799; FOXB1 HPA; HPA073369; - neXtProt; NX_Q99853; - OpenTargets; ENSG00000171956; - PharmGKB; PA28216; - eggNOG; KOG3562; Eukaryota eggNOG; COG5025; LUCA GeneTree; ENSGT00940000160522; - HOGENOM; HOG000007545; - HOVERGEN; HBG102104; - InParanoid; Q99853; - KO; K09395; - OMA; AWPHMYN; - OrthoDB; 1236900at2759; - PhylomeDB; Q99853; - TreeFam; TF350628; - GenomeRNAi; 27023; - PRO; PR:Q99853; - Proteomes; UP000005640; Chromosome 15 Bgee; ENSG00000171956; Expressed in 37 organ(s), highest expression level in substantia nigra Genevisible; Q99853; HS GO; GO:0005634; C:nucleus; ISS:UniProtKB GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central GO; GO:0007412; P:axon target recognition; ISS:UniProtKB GO; GO:0030154; P:cell differentiation; IBA:GO_Central GO; GO:0061381; P:cell migration in diencephalon; ISS:UniProtKB GO; GO:0061030; P:epithelial cell differentiation involved in mammary gland alveolus development; ISS:UniProtKB GO; GO:0033504; P:floor plate development; ISS:UniProtKB GO; GO:0021855; P:hypothalamus cell migration; ISS:UniProtKB GO; GO:0061379; P:inferior colliculus development; ISS:UniProtKB GO; GO:0007595; P:lactation; ISS:UniProtKB GO; GO:0061377; P:mammary gland lobule development; ISS:UniProtKB GO; GO:0021767; P:mammillary body development; ISS:UniProtKB GO; GO:0061374; P:mammillothalamic axonal tract development; ISS:UniProtKB GO; GO:0030901; P:midbrain development; ISS:UniProtKB GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central GO; GO:0001756; P:somitogenesis; ISS:UniProtKB GO; GO:0021510; P:spinal cord development; IEA:Ensembl GO; GO:0022029; P:telencephalon cell migration; ISS:UniProtKB GO; GO:0021794; P:thalamus development; IEA:Ensembl GO; GO:0001655; P:urogenital system development; IEA:Ensembl GO; GO:0008542; P:visual learning; ISS:UniProtKB CDD; cd00059; FH; 1 Gene3D; 1.10.10.10; -; 1 InterPro; IPR001766; Fork_head_dom InterPro; IPR018122; TF_fork_head_CS_1 InterPro; IPR030456; TF_fork_head_CS_2 InterPro; IPR036388; WH-like_DNA-bd_sf InterPro; IPR036390; WH_DNA-bd_sf Pfam; PF00250; Forkhead; 1 PRINTS; PR00053; FORKHEAD SMART; SM00339; FH; 1 SUPFAM; SSF46785; SSF46785; 1 PROSITE; PS00657; FORK_HEAD_1; 1 PROSITE; PS00658; FORK_HEAD_2; 1 PROSITE; PS50039; FORK_HEAD_3; 1 1: Evidence at protein level; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 325 Forkhead box protein B1 /FTId=PRO_0000091803 DNA_BIND 12 103 Fork-head. {ECO:0000255|PROSITE- ProRule:PRU00089} CONFLICT 65 65 L -> F (in Ref. 2; AAC09344) CONFLICT 106 106 R -> C (in Ref. 1; AAC62493 and 6; AAB47564). CONFLICT 126 126 Missing (in Ref. 1; AAC62493, 2; AAC09344 and 6; AAB47564). CONFLICT 171 173 AIE -> SIN (in Ref. 6; AAB47564) SEQUENCE 325 AA; 34978 MW; FAEE1B16B1997CB0 CRC64; MPRPGRNTYS DQKPPYSYIS LTAMAIQSSP EKMLPLSEIY KFIMDRFPYY RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PSCGDMFENG SFLRRRKRFK VLKSDHLAPS KPADAAQYLQ QQAKLRLSAL AASGTHLPQM PAAAYNLGGV AQPSGFKHPF AIENIIAREY KMPGGLAFSA MQPVPAAYPL PNQLTTMGSS LGTGWPHVYG SAGMIDSATP ISMASGDYSA YGVPLKPLCH AAGQTLPAIP VPIKPTPAAV PALPALPAPI PTLLSNSPPS LSPTSSQTAT SQSSPATPSE TLTSPASALH SVAVH
Research Areas
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References

The winged helix gene, Foxb1, controls development of mammary glands and regions of the CNS that regulate the milk-ejection reflex. Kloetzli JM, Fontaine-Glover IA, Brown ER, Kuo M, Labosky PA. Genesis. 2001 Feb;29(2):60-71. PMID: 11170346

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